Simple to useSimply insert the pessary into the vagina, with a finger as deep as possible, where it melts completely within a few minutes. If the vaginal walls are very sensitive, the use of Anime Lubricant can help with insertion.-Initial therapy: Insert 1x ovule before bedtime for 10 consecutive days. -Maintenance therapy: For a lasting effect, after the initial therapy,1x ovule every third day, for as long as you feel this is desirable. This regime has proven to be effective for the treatment and prevention of vaginal dryness. Side Effects and Contraindications -Since the ovules contain lactic acid, mild skin reactions (mild burning or itching) may occur in rare cases, particularly if the vaginal epithelium is very dry and/or damaged. These usually disappear within a short period.-Medical supervision is recommended if the ovules are used in acute or severe vaginal infections. -The product should not be used in known hypersensitivity to individual ingredients. -Risks for the unborn child are unknown, use during pregnancy is not recommended. -Since the ovules base contains modified natural fats, condoms or diaphragms made from natural latex should not be used at the same time as Premeno duo.